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Splicing alterations contributing to cancer hallmarks in the liver: central role of dedifferentiation and genome instability

Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. HCCs are molecularly heterogeneous tumors, and this complexity is to a great extent responsible for their poor response to conventional and targeted therapies. In this review we summarize recent evidence indicating th...

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Publicat a:Transl Gastroenterol Hepatol
Autors principals: Jimenez, Maddalen, Arechederra, María, Ávila, Matías A., Berasain, Carmen
Format: Artigo
Idioma:Inglês
Publicat: AME Publishing Company 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232053/
https://ncbi.nlm.nih.gov/pubmed/30505971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tgh.2018.10.11
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