Colonic Inhibition of Phosphatase and Tensin Homolog Increases Colitogenic Bacteria, Causing Development of Colitis in Il10(-/-) Mice

BACKGROUND: Phosphatase and tensin homolog (Pten) is capable of mediating microbe-induced immune responses in the gut. Thus, Pten deficiency in the intestine accelerates colitis development in Il10(-/-) mice. As some ambient pollutants inhibit Pten function and exposure to ambient pollutants may inc...

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Bibliografiske detaljer
Udgivet i:Inflamm Bowel Dis
Main Authors: Mitchell, Jonathon, Kim, Su Jin, Koukos, Georgios, Seelmann, Alexandra, Veit, Brendan, Shepard, Brooke, Blumer-Schuette, Sara, Winter, Harland S, Iliopoulos, Dimitrios, Pothoulakis, Charalabos, Im, Eunok, Rhee, Sang Hoon
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Original Basic Science Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231371/
https://ncbi.nlm.nih.gov/pubmed/29788382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ibd/izy124
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