The secreted glycolytic enzyme GPI/AMF stimulates glioblastoma cell migration and invasion in an autocrine fashion but can have anti-proliferative effects

BACKGROUND: Aerobic glycolysis confers several advantages to tumor cells, including shunting of metabolites into anabolic pathways. In glioblastoma cells, hypoxia induces a flux shift from the pentose phosphate pathway toward glycolysis and a switch from proliferation to migration. The mechanistic l...

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Udgivet i:Neuro Oncol
Main Authors: Kathagen-Buhmann, Annegret, Maire, Cecile L, Weller, Jonathan, Schulte, Alexander, Matschke, Jakob, Holz, Mareike, Ligon, Keith L, Glatzel, Markus, Westphal, Manfred, Lamszus, Katrin
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231211/
https://ncbi.nlm.nih.gov/pubmed/30053149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy117
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