The secreted glycolytic enzyme GPI/AMF stimulates glioblastoma cell migration and invasion in an autocrine fashion but can have anti-proliferative effects

BACKGROUND: Aerobic glycolysis confers several advantages to tumor cells, including shunting of metabolites into anabolic pathways. In glioblastoma cells, hypoxia induces a flux shift from the pentose phosphate pathway toward glycolysis and a switch from proliferation to migration. The mechanistic l...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Kathagen-Buhmann, Annegret, Maire, Cecile L, Weller, Jonathan, Schulte, Alexander, Matschke, Jakob, Holz, Mareike, Ligon, Keith L, Glatzel, Markus, Westphal, Manfred, Lamszus, Katrin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231211/
https://ncbi.nlm.nih.gov/pubmed/30053149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy117
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge