CaMKII-dependent late Na(+) current increases electrical dispersion and arrhythmia in ischemia-reperfusion

The mechanisms underlying Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-induced arrhythmias in ischemia-reperfusion (I/R) are not fully understood. We tested the hypothesis that CaMKII increases late Na(+) current (I(Na,L)) via phosphorylation of Na(v)1.5 at Ser(571) during I/R, thereby inc...

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Pubblicato in:Am J Physiol Heart Circ Physiol
Autori principali: Howard, Taylor, Greer-Short, Amara, Satroplus, Tony, Patel, Nehal, Nassal, Drew, Mohler, Peter J., Hund, Thomas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230905/
https://ncbi.nlm.nih.gov/pubmed/29932771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00197.2018
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