Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis

Colonic tissues in Inflammatory Bowel Disease (IBD) patients exhibit oxygen deprivation and activation of hypoxia-inducible factor 1α and 2α (HIF-1α and HIF-2α), which mediate cellular adaptation to hypoxic stress. Notably, macrophages and neutrophils accumulate preferentially in hypoxic regions of...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lin, Nan, Shay, Jessica E. S., Xie, Hong, Lee, David S. M., Skuli, Nicolas, Tang, Qiaosi, Zhou, Zilu, Azzam, Andrew, Meng, Hu, Wang, Haichao, FitzGerald, Garret A., Simon, M. Celeste
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230677/
https://ncbi.nlm.nih.gov/pubmed/30455703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02565
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