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In vitro Evidence That Combination Therapy With CD16-Bearing NK-92 Cells and FDA-Approved Alefacept Can Selectively Target the Latent HIV Reservoir in CD4+ CD2hi Memory T Cells

Elimination of the latent HIV reservoir remains the biggest hurdle to achieve HIV cure. In order to specifically eliminate HIV infected cells they must be distinguishable from uninfected cells. CD2 was recently identified as a potential marker enriched in the HIV-1 reservoir on CD4+ T cells, the lar...

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Pubblicato in:Front Immunol
Autori principali: Tomalka, Amanda G., Resto-Garay, Ivelisse, Campbell, Kerry S., Popkin, Daniel L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230627/
https://ncbi.nlm.nih.gov/pubmed/30455699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02552
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