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Mechanisms of NK Cell Activation and Clinical Activity of the Therapeutic SLAMF7 Antibody, Elotuzumab in Multiple Myeloma

Multiple myeloma (MM) is a bone marrow plasma cell neoplasm and is the second most-common hematologic malignancy. Despite advances in therapy, MM remains largely incurable. Elotuzumab is a humanized IgG1 monoclonal antibody targeting SLAMF7, which is highly expressed on myeloma cells, and the antibo...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Campbell, Kerry S., Cohen, Adam D., Pazina, Tatiana
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230619/
https://ncbi.nlm.nih.gov/pubmed/30455698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02551
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