N-Substituted Pyrido-1,4-Oxazin-3-Ones Induce Apoptosis of Hepatocellular Carcinoma Cells by Targeting NF-κB Signaling Pathway

Hepatocellular carcinoma (HCC) is a fatal disease and ranked fifth in cancer related mortality. Persistent activation of NF-κB is responsible for the oncogenesis, metastasis, tumor evasion, anti-apoptosis, angiogenesis and proliferation in HCC. Therefore, designing of chemically novel, biologically...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Mohan, Chakrabhavi Dhananjaya, Bharathkumar, Hanumantharayappa, Dukanya, Rangappa, Shobith, Shanmugam, Muthu K., Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Alahmadi, Tahani Awad, Bhattacharjee, Atanu, Lobie, Peter E., Deivasigamani, Amudha, Hui, Kam Man, Sethi, Gautam, Basappa, Rangappa, Kanchugarakoppal S., Kumar, Alan Prem
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230568/
https://ncbi.nlm.nih.gov/pubmed/30455641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01125
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