N-Substituted Pyrido-1,4-Oxazin-3-Ones Induce Apoptosis of Hepatocellular Carcinoma Cells by Targeting NF-κB Signaling Pathway

Hepatocellular carcinoma (HCC) is a fatal disease and ranked fifth in cancer related mortality. Persistent activation of NF-κB is responsible for the oncogenesis, metastasis, tumor evasion, anti-apoptosis, angiogenesis and proliferation in HCC. Therefore, designing of chemically novel, biologically...

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Pubblicato in:Front Pharmacol
Autori principali: Mohan, Chakrabhavi Dhananjaya, Bharathkumar, Hanumantharayappa, Dukanya, Rangappa, Shobith, Shanmugam, Muthu K., Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Alahmadi, Tahani Awad, Bhattacharjee, Atanu, Lobie, Peter E., Deivasigamani, Amudha, Hui, Kam Man, Sethi, Gautam, Basappa, Rangappa, Kanchugarakoppal S., Kumar, Alan Prem
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230568/
https://ncbi.nlm.nih.gov/pubmed/30455641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01125
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