TRPV4 Inhibition Improved Myelination and Reduced Glia Reactivity and Inflammation in a Cuprizone-Induced Mouse Model of Demyelination

The inhibition of demyelination and the promotion of remyelination are both considerable challenges in the therapeutic process for many central nervous system (CNS) diseases. Increasing evidence has demonstrated that neuroglial activation and neuroinflammation are responsible for myelin sheath damag...

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Pubblicato in:Front Cell Neurosci
Autori principali: Liu, Meiying, Liu, Xuan, Wang, Lei, Wang, Yu, Dong, Fuxing, Wu, Jian, Qu, Xuebin, Liu, Yanan, Liu, Zhian, Fan, Hongbin, Yao, Ruiqin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230558/
https://ncbi.nlm.nih.gov/pubmed/30455633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00392
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