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Changes in Biophysical Characteristics of PFN1 Due to Mutation Causing Amyotrophic Lateral Sclerosis
Single amino acid mutations in profilin 1 (PFN1) have been found to cause amyotrophic lateral sclerosis (ALS). Recently, we developed a mouse model for ALS using a PFN1 mutation (glycine 118 to valine, G118V), and we are now interested in understanding how PFN1 becomes toxically lethal with only one...
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| Publicat a: | Metab Brain Dis |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6230493/ https://ncbi.nlm.nih.gov/pubmed/30203378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11011-018-0305-4 |
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