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DNA DAMAGE: THE MOST STALWART PILLAR OF AGING

Aging has been attributed to stochastic damage to cellular components that accumulates over time. By genetically depleting DNA repair mechanisms in mice, we are able to evaluate the contribution of physiological types of levels of spontaneous DNA damage to the aging process. We found that in mice an...

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Bibliographic Details
Published in:Innov Aging
Main Author: Niedernhofer, L J
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6228501/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igy023.2198
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