NEW INSIGHTS INTO THE PROTEASOME FUNCTION AND DEGRADATION OF MISFOLDED PROTEINS

Protein degradation by the UPS is controlled through ubiquitin conjugation and control of proteasome activity. Most 26S proteasomes are in a latent state, but bindings of ubiquitinated proteins enhance its capacity to hydrolyze substrates and stimulates binding of key cofactors. Proteasome function...

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Bibliografiska uppgifter
I publikationen:Innov Aging
Huvudupphovsmän: Goldberg, A, Lokireddy, S, Kim, H, Kuo, C, VerPlank, J
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2018
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Abstracts
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6228170/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igy023.1443
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