Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosis

Lung fibroblasts play a pivotal role in pulmonary fibrosis, a devastating lung disease, by producing extracellular matrix. MicroRNAs (miRNAs) suppress numerous genes post-transcriptionally; however, the roles of miRNAs in activated fibroblasts in fibrotic lungs remain poorly understood. To elucidate...

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Udgivet i:Sci Rep
Main Authors: Souma, Kunihiko, Shichino, Shigeyuki, Hashimoto, Shinichi, Ueha, Satoshi, Tsukui, Tatsuya, Nakajima, Takuya, Suzuki, Hiroshi I., Shand, Francis H. W., Inagaki, Yutaka, Nagase, Takahide, Matsushima, Kouji
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226532/
https://ncbi.nlm.nih.gov/pubmed/30413725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34839-0
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