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Reduction of Proliferating Olfactory Cells and Low Expression of Extracellular Matrix Genes Are Hallmarks of the Aged Olfactory Mucosa

Background: The incidence of olfactory impairment increases with age; however, the detailed molecular and cellular mechanisms underlying this increase are yet to be determined. Methods: We examined the influence of aging on olfactory receptor neurons (ORNs), which are maintained by a unique stem cel...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Ueha, Rumi, Shichino, Shigeyuki, Ueha, Satoshi, Kondo, Kenji, Kikuta, Shu, Nishijima, Hironobu, Matsushima, Kouji, Yamasoba, Tatsuya
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880952/
https://ncbi.nlm.nih.gov/pubmed/29636678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2018.00086
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