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ATM Deficiency Promotes Progression of CRPC by Enhancing Warburg Effect
ATM is a well-known master regulator of double strand break (DSB) DNA repair and the defective DNA repair has been therapeutically exploited to develop PARP inhibitors based on the synthetic lethality strategy. ATM mutation is found with increased prevalence in advanced metastatic castration resista...
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| Publicat a: | Endocr Relat Cancer |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6226046/ https://ncbi.nlm.nih.gov/pubmed/30400006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-18-0196 |
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