Identification of key pathways and metabolic fingerprints of longevity in C. elegans

Impaired insulin/IGF-1 signaling (IIS) and caloric restriction (CR) prolong lifespan in the nematode C. elegans. However, a cross comparison of these longevity pathways using a multi-omics integration approach is lacking. In this study, we aimed to identify key pathways and metabolite fingerprints o...

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Udgivet i:Exp Gerontol
Main Authors: Gao, Arwen W., Smith, Reuben L., van Weeghel, Michel, Kamble, Rashmi, Janssens, Georges E., Houtkooper, Riekelt H.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224709/
https://ncbi.nlm.nih.gov/pubmed/30300667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2018.10.003
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