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ZNF598 Is a Quality Control Sensor of Collided Ribosomes

Aberrantly slow translation elicits quality control pathways initiated by the ubiquitin ligase ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and ubiquitinates stalled ribosomes selectively is unclear. Here, we find that the minimal unit engaged by ZNF598 is the c...

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Bibliografiska uppgifter
I publikationen:Mol Cell
Huvudupphovsmän: Juszkiewicz, Szymon, Chandrasekaran, Viswanathan, Lin, Zhewang, Kraatz, Sebastian, Ramakrishnan, V., Hegde, Ramanujan S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224477/
https://ncbi.nlm.nih.gov/pubmed/30293783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.037
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