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ZNF598 Is a Quality Control Sensor of Collided Ribosomes

Aberrantly slow translation elicits quality control pathways initiated by the ubiquitin ligase ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and ubiquitinates stalled ribosomes selectively is unclear. Here, we find that the minimal unit engaged by ZNF598 is the c...

詳細記述

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書誌詳細
出版年:Mol Cell
主要な著者: Juszkiewicz, Szymon, Chandrasekaran, Viswanathan, Lin, Zhewang, Kraatz, Sebastian, Ramakrishnan, V., Hegde, Ramanujan S.
フォーマット: Artigo
言語:Inglês
出版事項: Cell Press 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224477/
https://ncbi.nlm.nih.gov/pubmed/30293783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.037
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