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ZNF598 Is a Quality Control Sensor of Collided Ribosomes

Aberrantly slow translation elicits quality control pathways initiated by the ubiquitin ligase ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and ubiquitinates stalled ribosomes selectively is unclear. Here, we find that the minimal unit engaged by ZNF598 is the c...

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Bibliografiset tiedot
Julkaisussa:Mol Cell
Päätekijät: Juszkiewicz, Szymon, Chandrasekaran, Viswanathan, Lin, Zhewang, Kraatz, Sebastian, Ramakrishnan, V., Hegde, Ramanujan S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cell Press 2018
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224477/
https://ncbi.nlm.nih.gov/pubmed/30293783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.037
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