Age-dependent methylation in epigenetic clock CpGs is associated with G-quadruplex, co-transcriptionally formed RNA structures and tentative splice sites

Horvath’s epigenetic clock consists of 353 CpGs whose methylation levels can accurately predict the age of individuals. Using bioinformatics analysis, we investigated the conformation, energy characteristics and presence of tentative splice sites of the sequences surrounding the epigenetic clock CpG...

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Publicado en:Epigenetics
Autores principales: Malousi, Andigoni, Andreou, Alexandra-Zoi, Georgiou, Elisavet, Tzimagiorgis, Georgios, Kovatsi, Leda, Kouidou, Sofia
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224212/
https://ncbi.nlm.nih.gov/pubmed/30270726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2018.1514232
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