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Optimization of peptides that actively cross the tympanic membrane by random amino acid extension: A phage display study

Local treatment of middle ear (ME) disease currently requires surgical penetration of the tympanic membrane (TM). We previously discovered 12-mer peptides that are actively transported across the intact TM, a process that could be used for noninvasive drug delivery into the ME. To optimize transport...

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Pubblicato in:J Drug Target
Autori principali: Kurabi, Arwa, Schaerer, Daniel, Chang, Lisa, Pak, Kwang, Ryan, Allen F
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223256/
https://ncbi.nlm.nih.gov/pubmed/28658990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/1061186X.2017.1347791
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