Chalcones Repressed the AURKA and MDR Proteins Involved in Metastasis and Multiple Drug Resistance in Breast Cancer Cell Lines

In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20)....

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Pubblicato in:Molecules
Autori principali: Komoto, Tatiana Takahasi, Bernardes, Tayná Minervina, Mesquita, Thaís Balthazar, Bortolotto, Luis Felipe Buso, Silva, Gabriel, Bitencourt, Tamires Aparecida, Baek, Seung Joon, Marins, Mozart, Fachin, Ana Lúcia
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222917/
https://ncbi.nlm.nih.gov/pubmed/30104527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23082018
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