Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum

BACKGROUND: Fatty acid synthase (FAS) is a promising antifungal target due to its marked structural differences between fungal and mammalian cells. The aim of this study was to evaluate the antifungal activity of flavonoids described in the scientific literature as FAS inhibitors (quercetin, trans-c...

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Main Authors: Bitencourt, Tamires Aparecida, Komoto, Tatiana Takahasi, Massaroto, Bruna Gabriele, Miranda, Carlos Eduardo Saraiva, Beleboni, Rene Oliveira, Marins, Mozart, Fachin, Ana Lúcia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849095/
https://ncbi.nlm.nih.gov/pubmed/24044691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6882-13-229
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