Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum

BACKGROUND: Fatty acid synthase (FAS) is a promising antifungal target due to its marked structural differences between fungal and mammalian cells. The aim of this study was to evaluate the antifungal activity of flavonoids described in the scientific literature as FAS inhibitors (quercetin, trans-c...

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Detaylı Bibliyografya
Asıl Yazarlar: Bitencourt, Tamires Aparecida, Komoto, Tatiana Takahasi, Massaroto, Bruna Gabriele, Miranda, Carlos Eduardo Saraiva, Beleboni, Rene Oliveira, Marins, Mozart, Fachin, Ana Lúcia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849095/
https://ncbi.nlm.nih.gov/pubmed/24044691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6882-13-229
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