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Design, Synthesis and Docking Studies of Novel Macrocyclic Pentapeptides as Anticancer Multi-Targeted Kinase Inhibitors

A series of macrocyclic pyrido-pentapeptide candidates 2–6 were synthesized by using N,N-bis-[1-carboxy-2-(benzyl)]-2,6-(diaminocarbonyl)pyridine 1a,b as starting material. Structures of the newly synthesized compounds were established by IR, (1)H and (13)C-NMR, and MS spectral data and elemental an...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Molecules
Main Authors: Amr, Abd El-Galil E., Abo-Ghalia, Mohamed H., Moustafa, Gaber O., Al-Omar, Mohamed A., Nossier, Eman S., Elsayed, Elsayed A.
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222410/
https://ncbi.nlm.nih.gov/pubmed/30241374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23102416
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