A high-throughput real-time in vitro assay using mitochondrial targeted roGFP for screening of drugs targeting mitochondria

Most toxic compounds including cancer drugs target mitochondria culminating in its permeabilization. Cancer drug-screening and toxicological testing of compounds require cost-effective and sensitive high-throughput methods to detect mitochondrial damage. Real-time methods for detection of mitochondr...

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Bibliographische Detailangaben
Veröffentlicht in:Redox Biol
Hauptverfasser: Chandrasekharan, Aneesh, Varadarajan, Shankara Narayanan, Lekshmi, Asha, Lupitha, Santhik Subhasingh, Darvin, Pramod, Chandrasekhar, Leena, Pillai, Prakash Rajappan, Santhoshkumar, T.R., Pillai, M. Radhakrishna
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222140/
https://ncbi.nlm.nih.gov/pubmed/30408753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.10.013
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