The CDK9–cyclin T1 complex mediates saturated fatty acid–induced vascular calcification by inducing expression of the transcription factor CHOP

Vascular calcification (or mineralization) is a common complication of chronic kidney disease (CKD) and is closely associated with increased mortality and morbidity rates. We recently reported that activation of the activating transcription factor 4 (ATF4) pathway through the saturated fatty acid (S...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Shiozaki, Yuji, Okamura, Kayo, Kohno, Shohei, Keenan, Audrey L., Williams, Kristina, Zhao, Xiaoyun, Chick, Wallace S., Miyazaki-Anzai, Shinobu, Miyazaki, Makoto
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Lipids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222109/
https://ncbi.nlm.nih.gov/pubmed/30209133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004706
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