A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins

Recent evidence has revealed that heterotrimeric G-proteins can be activated by cytoplasmic proteins that share an evolutionarily conserved sequence called the Gα-binding-and-activating (GBA) motif. This mechanism provides an alternative to canonical activation by G-protein–coupled receptors (GPCRs)...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Maziarz, Marcin, Broselid, Stefan, DiGiacomo, Vincent, Park, Jong-Chan, Luebbers, Alex, Garcia-Navarrete, Lucia, Blanco-Canosa, Juan B., Baillie, George S., Garcia-Marcos, Mikel
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2018
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222092/
https://ncbi.nlm.nih.gov/pubmed/30194280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003580
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