Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system required for autophagosome formation, maturation and closure. Members of the ATG4 and the LC3/GABARAP family have been implicated in various diseases including cancer, and targeting the ATG4B protease has been suggeste...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Pengo, Niccolo, Prak, Krisna, Costa, Joana R., Luft, Christin, Agrotis, Alexander, Freeman, Jamie, Gewinner, Christina A., Chan, A. W. Edith, Selwood, David L., Kriston-Vizi, Janos, Ketteler, Robin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6221980/
https://ncbi.nlm.nih.gov/pubmed/30443548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2018.00148
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