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Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game

The study involves exploring the three orthogonal sites for aromatic nucleophilic substitution in cyanuric chloride (TCT). The preferential order of incorporation of different nucleophiles (such as alcohol, thiol, and amine) was addressed both experimentally and theoretically. The preferential order...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Sharma, Anamika, El-Faham, Ayman, de la Torre, Beatriz G., Albericio, Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6221914/
https://ncbi.nlm.nih.gov/pubmed/30443543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2018.00516
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