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Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game

The study involves exploring the three orthogonal sites for aromatic nucleophilic substitution in cyanuric chloride (TCT). The preferential order of incorporation of different nucleophiles (such as alcohol, thiol, and amine) was addressed both experimentally and theoretically. The preferential order...

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Pubblicato in:Front Chem
Autori principali: Sharma, Anamika, El-Faham, Ayman, de la Torre, Beatriz G., Albericio, Fernando
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6221914/
https://ncbi.nlm.nih.gov/pubmed/30443543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2018.00516
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