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Tin-Free Access to the ABC Core of the Calyciphylline A Alkaloids and Unexpected Formation of a D-Ring-Contracted Tetracyclic Core

A tin-free strategy for the successful cyclization of a variety of internal alkyne-containing N-chloroamine precursors to the ABC core via cyclization of a neutral aminyl radical is established. Deuterium labeling experiments confirm that the solvent is the primary source of the final H atom in the...

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Publicat a:Org Lett
Autors principals: Lopez, Alberto M., Ibrahim, Ahmad A., Rosenhauer, Gregory J., Sirinimal, Hansamali S., Stockdill, Jennifer L.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6221184/
https://ncbi.nlm.nih.gov/pubmed/29613805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b00544
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