Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model

BACKGROUND: Altered neuronal development is discussed as the underlying pathogenic mechanism of autism spectrum disorders (ASD). Copy number variations of 16p11.2 have recurrently been identified in individuals with ASD. Of the 29 genes within this region, quinolinate phosphoribosyltransferase (QPRT...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Mol Autism
Auteurs principaux: Haslinger, Denise, Waltes, Regina, Yousaf, Afsheen, Lindlar, Silvia, Schneider, Ines, Lim, Chai K., Tsai, Meng-Miao, Garvalov, Boyan K., Acker-Palmer, Amparo, Krezdorn, Nicolas, Rotter, Björn, Acker, Till, Guillemin, Gilles J., Fulda, Simone, Freitag, Christine M., Chiocchetti, Andreas G.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220561/
https://ncbi.nlm.nih.gov/pubmed/30443311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-018-0239-z
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires