Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model

BACKGROUND: Altered neuronal development is discussed as the underlying pathogenic mechanism of autism spectrum disorders (ASD). Copy number variations of 16p11.2 have recurrently been identified in individuals with ASD. Of the 29 genes within this region, quinolinate phosphoribosyltransferase (QPRT...

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Veröffentlicht in:Mol Autism
Hauptverfasser: Haslinger, Denise, Waltes, Regina, Yousaf, Afsheen, Lindlar, Silvia, Schneider, Ines, Lim, Chai K., Tsai, Meng-Miao, Garvalov, Boyan K., Acker-Palmer, Amparo, Krezdorn, Nicolas, Rotter, Björn, Acker, Till, Guillemin, Gilles J., Fulda, Simone, Freitag, Christine M., Chiocchetti, Andreas G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220561/
https://ncbi.nlm.nih.gov/pubmed/30443311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-018-0239-z
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