Synthesis and Preclinical Evaluation of the First Carbon-11 Labeled PET Tracers Targeting Substance P(1–7)

[Image: see text] Two potent SP(1–7) peptidomimetics have been successfully radiolabeled via [(11)C]CO(2)-fixation with excellent yields, purity, and molar activity. l-[(11)C]SP(1–7)-peptidomimetic exhibited promising ex vivo biodistribution profile. Metabolite analysis showed that l-[(11)C]SP(1–7)-...

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Publicado en:Mol Pharm
Autores principales: Pekošak, Aleksandra, Bulc, Janez Ž., Korat, Špela, Schuit, Robert C., Kooijman, Esther, Vos, Ricardo, Rongen, Marissa, Verlaan, Mariska, Takkenkamp, Kevin, Beaino, Wissam, Poot, Alex J., Windhorst, Albert D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2018
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220361/
https://ncbi.nlm.nih.gov/pubmed/30335399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00518
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