A CARD9 Founder Mutation Disrupts NF-κB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation

Background: Inherited CARD9 deficiency constitutes a primary immunodeficiency predisposing uniquely to chronic and invasive fungal infections. Certain mutations are shown to negatively impact CARD9 protein expression and/or NF-κB activation, but the underlying biochemical mechanism remains to be ful...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: De Bruyne, Marieke, Hoste, Levi, Bogaert, Delfien J., Van den Bossche, Lien, Tavernier, Simon J., Parthoens, Eef, Migaud, Mélanie, Konopnicki, Deborah, Yombi, Jean Cyr, Lambrecht, Bart N., van Daele, Sabine, Alves de Medeiros, Ana Karina, Brochez, Lieve, Beyaert, Rudi, De Baere, Elfride, Puel, Anne, Casanova, Jean-Laurent, Goffard, Jean-Christophe, Savvides, Savvas N., Haerynck, Filomeen, Staal, Jens, Dullaers, Melissa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220056/
https://ncbi.nlm.nih.gov/pubmed/30429846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02366
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