A CARD9 Founder Mutation Disrupts NF-κB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation

Background: Inherited CARD9 deficiency constitutes a primary immunodeficiency predisposing uniquely to chronic and invasive fungal infections. Certain mutations are shown to negatively impact CARD9 protein expression and/or NF-κB activation, but the underlying biochemical mechanism remains to be ful...

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Pubblicato in:Front Immunol
Autori principali: De Bruyne, Marieke, Hoste, Levi, Bogaert, Delfien J., Van den Bossche, Lien, Tavernier, Simon J., Parthoens, Eef, Migaud, Mélanie, Konopnicki, Deborah, Yombi, Jean Cyr, Lambrecht, Bart N., van Daele, Sabine, Alves de Medeiros, Ana Karina, Brochez, Lieve, Beyaert, Rudi, De Baere, Elfride, Puel, Anne, Casanova, Jean-Laurent, Goffard, Jean-Christophe, Savvides, Savvas N., Haerynck, Filomeen, Staal, Jens, Dullaers, Melissa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220056/
https://ncbi.nlm.nih.gov/pubmed/30429846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02366
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