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IL-1α and not IL-1β drives IL-1R1-dependent neonatal murine sepsis lethality

Sepsis disproportionately affects the very old and the very young. IL-1 signaling is important in innate host defense but may also play a deleterious role in acute inflammatory conditions including sepsis by promulgating life-threatening inflammation. IL-1 signaling is mediated by two distinct ligan...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Benjamin, John T., Moore, Daniel J., Bennett, Clayton, van der Meer, Riet, Royce, Ashley, Loveland, Ryan, Wynn, James L.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219910/
https://ncbi.nlm.nih.gov/pubmed/30305325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801089
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