Differential activation of hepatic iNKT cell subsets plays a key role in progression of nonalcoholic steatohepatitis

Innate immune mechanisms play an important role in inflammatory chronic liver diseases. Here, we investigated the role of type I natural killer T (or iNKT) cell subsets in the progression of nonalcoholic steatohepatitis (NASH). We used α-galactosylceramide (αGalCer)/CD1d tetramers and clonotypic mAb...

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Udgivet i:J Immunol
Main Authors: Maricic, Igor, Marrero, Idania, Eguchi, Akiko, Nakamura, Ryota, Johnson, Casey D., Dasgupta, Suryasarathi, Hernandez, Carolyn D., Nguyen, Phirum Sam, Swafford, Austin D., Knight, Rob, Feldstein, Ariel E., Loomba, Rohit, Kumar, Vipin
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219905/
https://ncbi.nlm.nih.gov/pubmed/30322964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800614
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