Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5

MHCII in antigen-presenting cells (APCs) is a key regulator of adaptive immune responses. Expression of MHCII genes is controlled by the transcription coactivator CIITA, itself regulated through cell type–specific promoters. Here we show that the transcription factor NFAT5 is needed for expression o...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Buxadé, Maria, Huerga Encabo, Hector, Riera-Borrull, Marta, Quintana-Gallardo, Lucía, López-Cotarelo, Pilar, Tellechea, Mónica, Martínez-Martínez, Sara, Redondo, Juan Miguel, Martín-Caballero, Juan, Flores, Juana María, Bosch, Elena, Rodríguez-Fernández, José Luis, Aramburu, Jose, López-Rodríguez, Cristina
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219740/
https://ncbi.nlm.nih.gov/pubmed/30327417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180314
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