Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5

MHCII in antigen-presenting cells (APCs) is a key regulator of adaptive immune responses. Expression of MHCII genes is controlled by the transcription coactivator CIITA, itself regulated through cell type–specific promoters. Here we show that the transcription factor NFAT5 is needed for expression o...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Buxadé, Maria, Huerga Encabo, Hector, Riera-Borrull, Marta, Quintana-Gallardo, Lucía, López-Cotarelo, Pilar, Tellechea, Mónica, Martínez-Martínez, Sara, Redondo, Juan Miguel, Martín-Caballero, Juan, Flores, Juana María, Bosch, Elena, Rodríguez-Fernández, José Luis, Aramburu, Jose, López-Rodríguez, Cristina
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219740/
https://ncbi.nlm.nih.gov/pubmed/30327417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180314
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