Human monocytes and macrophages regulate immune tolerance via integrin αvβ8–mediated TGFβ activation

Monocytes are crucial immune cells involved in regulation of inflammation either directly or via differentiation into macrophages in tissues. However, many aspects of how their function is controlled in health and disease are not understood. Here we show that human blood monocytes activate high leve...

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Vydáno v:J Exp Med
Hlavní autoři: Kelly, Aoife, Gunaltay, Sezin, McEntee, Craig P., Shuttleworth, Elinor E., Smedley, Catherine, Houston, Stephanie A., Fenton, Thomas M., Levison, Scott, Mann, Elizabeth R., Travis, Mark A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219736/
https://ncbi.nlm.nih.gov/pubmed/30355614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171491
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