Human monocytes and macrophages regulate immune tolerance via integrin αvβ8–mediated TGFβ activation

Monocytes are crucial immune cells involved in regulation of inflammation either directly or via differentiation into macrophages in tissues. However, many aspects of how their function is controlled in health and disease are not understood. Here we show that human blood monocytes activate high leve...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Kelly, Aoife, Gunaltay, Sezin, McEntee, Craig P., Shuttleworth, Elinor E., Smedley, Catherine, Houston, Stephanie A., Fenton, Thomas M., Levison, Scott, Mann, Elizabeth R., Travis, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219736/
https://ncbi.nlm.nih.gov/pubmed/30355614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171491
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