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Touchscreen testing reveals clinically relevant cognitive abnormalities in a mouse model of schizophrenia lacking metabotropic glutamate receptor 5

Metabotropic glutamate receptor 5 (mGlu5) has been implicated in certain forms of synaptic plasticity and cognitive function. mGlu5 knockout (KO) mice and mGlu5 antagonists have been previously used to study the pathophysiology of schizophrenia as they have been shown respectively to display or indu...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Zeleznikow-Johnston, Ariel M., Renoir, Thibault, Churilov, Leonid, Li, Shanshan, Burrows, Emma L., Hannan, Anthony J.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219561/
https://ncbi.nlm.nih.gov/pubmed/30401923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33929-3
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