Nanoformulated paclitaxel and AZD9291 synergistically eradicate non-small-cell lung cancers in vivo

AIM: This study aims to develop new nanoformulations of EGFR T790M targeted inhibitor AZD9291 and paclitaxel (PTX) for combination therapy of lung cancer. MATERIALS & METHODS: We prepared and characterized PTX- and AZD9291-loaded disulfide cross-linking micelles (DCMs), and evaluate their combin...

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Detalhes bibliográficos
Publicado no:Nanomedicine (Lond)
Main Authors: Wang, Xin-shuai, Zhang, Li, Li, Xiaocen, Kong, De-jiu, Hu, Xiao-chen, Ding, Xue-zhen, Yang, Jun-qiang, Zhao, Meng-qi, He, Yixuan, Lam, Kit S, Gao, She-gan, Lin, Tzu-yin, Li, Yuanpei
Formato: Artigo
Idioma:Inglês
Publicado em: Future Medicine Ltd 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219431/
https://ncbi.nlm.nih.gov/pubmed/29874151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm-2017-0355
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