Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

Protein N-glycosylation is a widespread post-translational modification. The first committed step in this process is catalysed by dolichyl-phosphate N-acetylglucosamine-phosphotransferase DPAGT1 (GPT/E.C. 2.7.8.15). Missense DPAGT1 variants cause congenital myasthenic syndrome and disorders of glyco...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cell
Auteurs principaux: Dong, Yin Yao, Wang, Hua, Pike, Ashley C.W., Cochrane, Stephen A., Hamedzadeh, Sadra, Wyszyński, Filip J., Bushell, Simon R., Royer, Sylvain F., Widdick, David A., Sajid, Andaleeb, Boshoff, Helena I., Park, Yumi, Lucas, Ricardo, Liu, Wei-Min, Lee, Seung Seo, Machida, Takuya, Minall, Leanne, Mehmood, Shahid, Belaya, Katsiaryna, Liu, Wei-Wei, Chu, Amy, Shrestha, Leela, Mukhopadhyay, Shubhashish M.M., Strain-Damerell, Claire, Chalk, Rod, Burgess-Brown, Nicola A., Bibb, Mervyn J., Barry III, Clifton E., Robinson, Carol V., Beeson, David, Davis, Benjamin G., Carpenter, Elisabeth P.
Format: Artigo
Langue:Inglês
Publié: Cell Press 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218659/
https://ncbi.nlm.nih.gov/pubmed/30388443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.10.037
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires