The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C

The compound MCI-154 was previously shown to increase the calcium sensitivity of cardiac muscle contraction. Using solution NMR spectroscopy, we demonstrate that MCI-154 interacts with the calcium-sensing subunit of the cardiac troponin complex, cardiac troponin C (cTnC). Surprisingly, however, it b...

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Publicat a:Biochem Biophys Rep
Autors principals: Li, Monica X., Gelozia, Shorena, Danmaliki, Gaddafi I., Wen, Yurong, Liu, Philip B., Lemieux, M. Joanne, West, Frederick G., Sykes, Brian D., Hwang, Peter M.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218639/
https://ncbi.nlm.nih.gov/pubmed/30417133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2018.10.012
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