Constitutive Activation of NF-κB Pathway in Hematopoietic Stem Cells Causes Loss of Quiescence and Deregulated Transcription Factor Networks

Identifying physiological roles of specific signaling pathways that regulate hematopoietic stem cell (HSC) functions may lead to new treatment strategies and therapeutic interventions for hematologic disorders. Here, we provide genetic evidence that constitutive activation of NF-κB in HSCs results i...

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Detalles Bibliográficos
Publicado en:Front Cell Dev Biol
Autores principales: Nakagawa, Masahiro Marshall, Chen, Huanwen, Rathinam, Chozha Vendan
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Cell and Developmental Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218573/
https://ncbi.nlm.nih.gov/pubmed/30425986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2018.00143
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