Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis

Many pro-inflammatory pathways leading to arthritis have global effects on the immune system rather than only acting locally in joints. The reason behind the regional and patchy distribution of arthritis represents a longstanding paradox. Here we show that biomechanical loading acts as a decisive fa...

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Publicat a:Nat Commun
Autors principals: Cambré, Isabelle, Gaublomme, Djoere, Burssens, Arne, Jacques, Peggy, Schryvers, Nadia, De Muynck, Amélie, Meuris, Leander, Lambrecht, Stijn, Carter, Shea, de Bleser, Pieter, Saeys, Yvan, Van Hoorebeke, Luc, Kollias, George, Mack, Matthias, Simoens, Paul, Lories, Rik, Callewaert, Nico, Schett, Georg, Elewaut, Dirk
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218475/
https://ncbi.nlm.nih.gov/pubmed/30397205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06933-4
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