Deregulation of the imprinted DLK1-DIO3 locus ncRNAs is associated with replicative senescence of human adipose-derived stem cells

BACKGROUND: Human adult adipose-derived stem cells (hADSCs) have become the most promising cell source for regenerative medicine. However the prolonged ex vivo expansion periods required to obtain the necessary therapeutic dose promotes progressive senescence, with the concomitant reduction of their...

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Udgivet i:PLoS One
Main Authors: García-López, Silvia, Albo-Castellanos, Carmen, Urdinguio, Rocio G., Cañón, Susana, Sánchez-Cabo, Fátima, Martínez-Serrano, Alberto, Fraga, Mario F., Bernad, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218046/
https://ncbi.nlm.nih.gov/pubmed/30395586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206534
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