Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action

[Image: see text] ATAD2 (ANCCA) is an epigenetic regulator and transcriptional cofactor, whose overexpression has been linked to the progress of various cancer types. Here, we report a DNA-encoded library screen leading to the discovery of BAY-850, a potent and isoform selective inhibitor that speci...

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Bibliografski detalji
Izdano u:ACS Chem Biol
Glavni autori: Fernández-Montalván, Amaury E., Berger, Markus, Kuropka, Benno, Koo, Seong Joo, Badock, Volker, Weiske, Joerg, Puetter, Vera, Holton, Simon J., Stöckigt, Detlef, ter Laak, Antonius, Centrella, Paolo A., Clark, Matthew A., Dumelin, Christoph E., Sigel, Eric A., Soutter, Holly H., Troast, Dawn M., Zhang, Ying, Cuozzo, John W., Keefe, Anthony D., Roche, Didier, Rodeschini, Vincent, Chaikuad, Apirat, Díaz-Sáez, Laura, Bennett, James M., Fedorov, Oleg, Huber, Kilian V. M., Hübner, Jan, Weinmann, Hilmar, Hartung, Ingo V., Gorjánácz, Mátyás
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2017
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218015/
https://ncbi.nlm.nih.gov/pubmed/29043777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00708
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