Distinct effector B-cells induced by unregulated Toll-like receptor 7 contribute to pathogenic responses in Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is characterized by B-cells lacking IgD and CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5(−)CD11c(+) cells (DN2) representing pre-plasma cells (PC). DN2 cells predominated in African-American patients with active disease an...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Jenks, Scott A., Cashman, Kevin S., Zumaquero, Esther, Marigorta, Urko M., Patel, Aakash V., Wang, Xiaoqian, Tomar, Deepak, Woodruff, Matthew C., Simon, Zoe, Bugrovsky, Regina, Blalock, Emily L., Scharer, Christopher D., Tipton, Christopher M., Wei, Chungwen, Lim, S. Sam, Petri, Michelle, Niewold, Timothy B., Anolik, Jennifer H., Gibson, Greg, Eun-Hyung Lee, F., Boss, Jeremy M., Lund, Frances E., Sanz, Ignacio
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217820/
https://ncbi.nlm.nih.gov/pubmed/30314758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.08.015
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados